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Brenda Coxe
Project P-118
Esclim
Generic Name: Estradiol topical patches
Brand Names: Alora, Climara, Esclim, Estraderm, Fempatch, Vivelle, Vivelle-Dol
What Is the Most Important Information About Estradiol Topical Patches?
A condition known as endometrial hyperplasia has the potential to cause cancer in the lining of the uterus. Using estradiol topical patches increase the risk of a woman developing this condition. In order to reduce the risk of developing this condition, another hormone drug, progestins, may be taken. The doctor may prescribe a progestin to be taken with estradiol topical patches for a woman who still has her uterus. During hormone therapy, it is important to visit your doctor regularly and report any unusual vaginal bleeding immediately.
The risk of stroke may increase because of long-term treatment with estrogens; therefore, you should contact your doctor or health care provider to assess the risks and benefits of estrogen therapy for your individual needs for the long-term. Every three to six months, a consultation with your doctor or health care provider should be arranged to discuss whether you should continue the treatment. In addition, while using the estradiol topical patches, you should be certain to have annual physical exams and perform a breast self-examination monthly to feel for any lumps.
The Women’s Health Initiative Memory Study (WHIMS) previously discovered that postmenopausal women over the age of 65 who had been treated with oral conjugated estrogens and medroxyprogesterone acetate were at an increased risk of developing dementia, however, it is not known if younger postmenopausal women are also at risk or if it includes women who are only using estrogen therapy.
The transdermal patch should not be placed on your breasts or at your waistline since tight-fitting clothing may interfere with its ability to function.
What Are Estradiol Topical Patches?
Estradiol is a form of estrogen. It is a female sex hormone required for many processes in the body. Estradiol topical patches are prescribed to treat several conditions, including but not limited to the following:
- Symptoms of menopause
- Ovary function deficiencies, which may include some types of infertility and abnormal vaginal bleeding
- Vaginal or urethral dryness, itching, or burning that are caused by hormonal deficiencies
- Prevention of postmenopausal osteoporosis
What Issues Should Be Discussed With My Health Care Provider Before Using Estradiol Topical Patches?
You should talk to your doctor before using estradiol topical patches if you have a circulation, bleeding, or blood clotting disorder, abnormal vaginal bleeding that has not be diagnosed, or any type of breast, uterine, or hormone-dependent cancer. Using the patch may be dangerous in some people with any of these conditions.
Before you begin therapy with an estradiol topical patch, make sure your doctor knows if you have any of the following conditions:
- High blood pressure, angina, or heart disease
- High cholesterol or triglyceride levels in your blood
- Liver disease
- Kidney disease
- Asthma
- Epilepsy
- Migraines
- Depression
- Diabetes
- Gallbladder disease
- Uterine fibroids
- Hysterectomy with uterus removed
Patients who have any of the above conditions may be unable to use the estradiol topical patch or may require a dosage adjustment or special monitoring during the therapy.
Estradiol has been placed in the FDA pregnancy category X, which means that the drug is known to cause birth defects in an unborn baby. Do not use estradiol topical patches if you are pregnant or may become pregnant during therapy. Additionally, it may cause a decrease in milk flow as well as other effects on milk composition, so you should not use the patches if you are breastfeeding without talking to your doctor first.
How Should Estradiol Topical Patches Be Used?
The patches should be used exactly as your doctor prescribed them. If you are unclear on the directions, ask your pharmacist, doctor, or health care provider. Do not touch the sticky side of the patch as you remove it from the protective backing. Once it has been removed, apply it immediately to a clean, dry area on your abdomen, buttocks, inner thigh, upper arm, or hips. Press firmly into place with the palm of your hand for about ten seconds.
Storage
Store the estradiol topical patches in their pouches at room temperature and away from moisture and heat.
Side Effects
If any of the following side effects occur, stop using the patches immediately and contact your doctor or health care provider:
- An allergic reaction such as breathing difficulty, closing of the throat, swelling of the lips, tongue, or face, or hives
- Shortness of breath or chest pain
- A painful, red, swollen leg
- Abnormal vaginal bleeding
- Abdominal pain, swelling, or tenderness
- Severe headache or vomiting, dizziness, faintness or vision or speech changes
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